Christoph Licht Selected Research

eculizumab

8/2020	Functional Assessment of Fatigue and Other Patient-Reported Outcomes in Patients Enrolled in the Global aHUS Registry.
10/2019	Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study.
4/2019	Eculizumab prevents thrombotic microangiopathy in patients with atypical haemolytic uraemic syndrome in a long-term observational study.
3/2018	Long-term Eculizumab Therapy in a Child With Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis.
1/2018	Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.
4/2016	The alternative pathway of complement and the thrombotic microangiopathies.
3/2016	Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome.
1/2016	CFH gene mutation in a case of Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS).
5/2015	Eculizumab hepatotoxicity in pediatric aHUS.
5/2015	Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies.

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Christoph Licht Research Topics

Disease

22	Atypical Hemolytic Uremic Syndrome 01/2022 - 02/2005
13	Thrombotic Microangiopathies 08/2020 - 02/2005
10	Hemolytic-Uremic Syndrome 12/2021 - 09/2004
9	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II) 01/2022 - 09/2007
9	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 02/2009
9	Proteinuria 01/2020 - 09/2007
8	Infections 12/2021 - 09/2004
8	Thrombotic Thrombocytopenic Purpura 01/2021 - 09/2004
8	Hypertension (High Blood Pressure) 12/2020 - 02/2009
5	Acute Kidney Injury (Acute Renal Failure) 12/2021 - 09/2004
4	Meningococcal Infections 10/2019 - 05/2015
4	Headache (Headaches) 01/2019 - 02/2014
4	Dizziness (Lightheadedness) 01/2019 - 02/2014
4	Respiratory Tract Infections (Respiratory Tract Infection) 09/2014 - 03/2009
3	Kidney Diseases (Kidney Disease) 01/2022 - 09/2005
3	Nephrotic Syndrome (Syndrome, Nephrotic) 03/2019 - 08/2010
3	Hemolytic Anemia 01/2018 - 09/2004
3	Glomerulonephritis 01/2017 - 02/2009
3	Rare Diseases (Rare Disease) 11/2016 - 01/2007
3	Hereditary Nephritis (Alport Syndrome) 07/2013 - 03/2009
3	Hematuria 04/2012 - 03/2009
2	Inflammation (Inflammations) 09/2021 - 06/2014
2	Chronic Renal Insufficiency 09/2021 - 05/2015
2	von Willebrand Diseases (von Willebrand's Disease) 01/2020 - 01/2016
2	Vasculitis (Vasculitides) 01/2018 - 06/2014
2	Thrombocytopenia (Thrombopenia) 01/2018 - 09/2004
2	Leukemia 01/2017 - 06/2013
2	Diarrhea 10/2014 - 04/2009
2	Neoplasms (Cancer) 03/2013 - 06/2011
2	Thrombosis (Thrombus) 06/2011 - 09/2009
2	Complement Factor H Deficiency 01/2007 - 02/2005
1	Stroke (Strokes) 01/2022
1	MELAS Syndrome (Syndrome, MELAS) 01/2022
1	Bone Diseases (Bone Disease) 09/2021
1	COVID-19 01/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2021
1	Vomiting 08/2020
1	Chronic Disease (Chronic Diseases) 08/2020
1	Nausea 08/2020
1	Fatigue 08/2020
1	Sepsis (Septicemia) 01/2020
1	Opsoclonus-Myoclonus Syndrome (Kinsbourne Syndrome) 01/2019
1	Muscle Cramp (Cramp) 01/2019
1	Pulmonary Arterial Hypertension 06/2018
1	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2018
1	Bronchitis 01/2017
1	Cysts 02/2016

Drug/Important Bio-Agent (IBA)

26	Complement System Proteins (Complement)IBA 01/2021 - 02/2005
17	eculizumab FDA Link 08/2020 - 09/2007
11	Complement Factor H (Factor H)IBA 01/2018 - 02/2005
6	Shiga Toxin (Shigella Toxin)IBA 12/2021 - 01/2016
6	AutoantibodiesIBA 01/2018 - 02/2008
5	thiamine triphosphorate (TTP)IBA 01/2018 - 09/2004
4	Complement C3 (C3 Complement)IBA 01/2022 - 11/2013
4	Proteins (Proteins, Gene)FDA Link 12/2020 - 02/2009
4	CreatinineIBA 12/2020 - 03/2009
3	Anti-Bacterial Agents (Antibiotics)IBA 04/2021 - 01/2006
3	von Willebrand FactorIBA 01/2021 - 01/2016
3	Antigen-Antibody Complex (Immune Complex)IBA 12/2020 - 01/2017
3	Antihypertensive Agents (Antihypertensives)IBA 09/2014 - 02/2014
2	Messenger RNA (mRNA)IBA 01/2020 - 04/2004
2	Complement Inactivating AgentsIBA 04/2019 - 05/2015
2	Pharmaceutical PreparationsIBA 11/2016 - 04/2014
2	SteroidsIBA 12/2013 - 08/2010
2	Dichlorodiphenyldichloroethane (DDD)IBA 02/2009 - 09/2007
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	dimemorfan (AT 17)IBA 01/2022
1	Immunoglobulins (Immunoglobulin)IBA 01/2022
1	A 17 (A-17)IBA 01/2022
1	Leu Transfer RNAIBA 01/2022
1	Arginine (L-Arginine)FDA Link 01/2022
1	Vancomycin FDA LinkGeneric 04/2021
1	Peptide Hydrolases (Proteases)FDA Link 01/2021
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2020
1	Puromycin AminonucleosideIBA 01/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2019
1	C-Reactive ProteinIBA 01/2019
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2019
1	Parathyroid Hormone (Parathormone)IBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 06/2018
1	ThrombospondinsIBA 06/2018
1	HomocysteineIBA 06/2018
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 06/2018
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2018
1	Membrane Cofactor ProteinIBA 01/2018
1	PlasticsIBA 01/2017
1	Monoclonal AntibodiesIBA 04/2016
1	Monomeric GTP-Binding ProteinsIBA 02/2016
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2016

Therapy/Procedure

21	Therapeutics 08/2020 - 02/2005
6	Kidney Transplantation 01/2022 - 09/2005
5	Renal Dialysis (Hemodialysis) 01/2022 - 01/2006
2	Hemodiafiltration 09/2021 - 04/2021
2	Critical Care (Surgical Intensive Care) 01/2021 - 01/2004
2	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2021 - 04/2012
2	Catheters 01/2020 - 01/2017
2	Transplantation 06/2014 - 10/2010
2	Drug Therapy (Chemotherapy) 06/2013 - 03/2013
1	Immunomodulation 01/2019
1	Blood Component Removal (Apheresis) 01/2017